No.
Name
Postion / Subject
1
Dong-Seok Yim Associate Professorr, The Catholic University, Korea
Looking into the population analysis of densely sampled pharmacokinetic data
2
Young-Ran Yoon Assistant Professor, Kyungpook National University, Korea
PK/PD modeling for fexofenadine with polysomsography
3
Kyung-Sang Yu Assistant Professor, Seoul National University, Korea
Application of PK-PD modeling and clinical trial simulation in drug development: Example of PET imaging biomarkers
4
Kyun-Seop Bae Assistant Professor, University of Ulsan, Korea
Population PK-PD Modeling of Clopidogrel
5
Suk-Jae Chung Associate Professor, Seoul National University, Korea
Functional Implication of Transporters on Pharmacokinetics during Nitrosative Stress
 
Profiles


Dong-Seok Yim


Biography

He is currently working as associate professor at the Dept. of Pharmacology of The Catholic University of Korea and chair of the Dept. of Clinical Pharmacology of Kangnam St. Mary’s Hospital in Seoul. After graduating from Seoul National University (SNU), College of Medicine in 1992 (M.D.), he got four years’ training of clinical pharmacology at the graduate school of SNU Ph.D.). His paper on the pop. PK of phenytoin in Korean patients then was the first study which used NONMEM software in Korea. After serving at Korea FDA for three years to fulfill military duty, he got two years’ international fellowship at the Center for Drug Development Science (CDDS) of Georgetown University (Director: Carl Peck). During the fellowship, he also worked as a visiting scientist at CDER, FDA. A population PK-PD project on glucose-HbA1c model and a simulation to compare the conventional and individual bioequivalence study data were projects led by him at CDER. Back in Korea since 2005, he has been leading his PK-PD lab of Clinical Research Cooperating Center (CRCC) of Catholic Univ., one of the regional clinical trial centers supported by Korean government.

A brief description of the presentation
He will briefly review the implication of mixed effect model approach in the data rich environment and share his experience obtained in the course of modeling with densely sampled pharmacokinetic data from several tens of subjects.


Young-Ran Yoon


Biography

Dr. Yoon is an Assistant Professor of Clinical Pharmacology at the Department of Molecular Medicine of the Kyungpook National University(KNU) School of Medicine, and is also working at the Clinical Trial Center of KNU Hospital in Daegu, Korea. After graduating from the College of Medicine, Inje University, she had studied and got her Ph.D. degree from Seoul National University in 1998. She worked on various clinical pharmacology research projects at Inje University until 2003. She had got her post-doctoral training in the Division of Clinical Pharmacology, University of California at San Francisco (mentors: Dr. Neal L Benowitz and Dr. Davide Verotta), from January, 2004 to June, 2005, and at present, she is working in KNU.
She is interested in drug metabolism and metabolomics, pharmacogenomics, and early phase clinical trials.

A brief description of the presentation
This presentation is about the differences in nocturnal polysomnographic characteristics between two drugs of different generations of anti-histaminergics, fexofenadine and chloropheniramine. And the pharmacokinetics of fexofenadine was modeled with its sleep electroencephalogram(EEG) information.


Kyung-Sang Yu

Biography

Dr. Yu is currently an Assistant Professor of Clinical Pharmacology at the College of Medicine, Seoul National University (SNU), and is also affiliated to the Clinical Trial Center of Seoul National University Hospital (SNUH). After graduating from the College of Medicine, SNU, he has taken an internship at SNUH, and went on to be trained in the clinical pharmacology residency program there. He has received his Ph.D. from this university in 2000, and has been involved in many clinical pharmacology study projects.
He is interested in various fields related to early phase clinical trials and pharmacogenomic research.


A brief description of the presentation
This talk will focus on a case of a novel antipsychotic agent, in which serial PET images in healthy volunteers were used to estimate brain D2 receptor occupancies. Using this information combined with blood concentrations, a PK-PD model was developed, and clinical trial simulation was conducted in order to optimize designs for further trials in patients.


Kyun-Seop Bae

Biography
Dr. Bae is an assistant professor at the Department of Clinical Pharmacology and Therapeutics of Asan Medical Center and University of Ulsan, Korea. He graduated from Seoul National University College of Medicine in 1994. After internship and residency of clinical pharmacology at Seoul National University Hospital, he joined Asan Medical Center in 2002. He conducted more than 20 phase 1 clinical trials as a principal investigator at Asan Medical Center since 2003. He also actively involved in developing clinical research center at Asan Medical Center. His academic interests are pharmacometrics and developing software for clinical pharmacology.

A brief description of the presentation
Clopidogrel is an inhibitor of ADP induced platelet aggregation and widely used for ischemic heart disease and ischemic stroke. We measured parent and metabolite of clopidorel, and tested platelet aggregation function in 70 healthy volunteers. We also explored the effect of CYP enzyme geontype and ADP receptor genotype.


Suk-Jae Chung

Biography
Dr. Suk-Jae Chung is currently an associate professor of Pharmaceutical Sciences at the College of Pharmacy, Seoul National University. After graduating from Seoul National University, College of Pharmacy in 1984
(B.S.) and 1986 (M.S.), he received his Ph. D. degree from the Department of Pharmaceutics, State University of New York at Buffalo (1992) under the guidance of Professor Ho-Leung Fung. Dr. Chung got his post-doctoral training in the Department of Pharmaceutical Sciences, University of California at San Francisco (supervisor: Professor Kathleen Giacomini). Dr. Chung’s primary research interests include the functional implication of transporter, OAT3 and MDR, in the alteration of pharmacokinetics during disease states associated with nitrosative stress.

A brief description of the presentation
In this presentation, two lines of investigation will be presented for alterations in functional activities of carriers expressed in barriers of between the systemic circulation and the brain, and the resulting pharmacokinetics by nitrogen oxide (NOx) forms.

 
 

Secretariat of PKPD Yonsei 2006: c/o Ms. Ji Hye Lee, Clinical Trials Center, Yonsei University Medical Center
134 Shinchon-Dong, Seoul 120-752, Korea, Tel: +82-2-2228-0479 / Fax: +82-2-392-0668, E-mail: illlee@yumc.yonsei.ac.kr